Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can
rapidly respond against pathogens and tumors in an antigen-independent manner and then …

Reactive oxygen species (ROS) are a group of highly reactive chemicals containing oxygen
produced either exogenously or endogenously. ROS are related to a wide variety of human …

Somatic recombination of TCR genes in immature thymocytes results in some cells with
useful TCR specificities, but also many with useless or potentially self-reactive specificities …

Natural killer (NK) cells survey host tissues for signs of infection, transformation or stress
and, true to their name, kill target cells that have become useless or are detrimental to the …

Antiviral CD8+ T cell responses are characterized by an initial activation/priming of T
lymphocytes followed by a massive proliferation, subset differentiation, population …

Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed
by proteases called caspases. The Bcl2 family of intracellular proteins is the central …

Clinical response to chimeric antigen receptor (CAR) T cell therapy is correlated with CAR T
cell persistence, especially for CAR T cells that target CD19+ hematologic malignancies. 4 …

Impaired apoptosis is both critical in cancer development and a major barrier to effective
treatment. In response to diverse intracellular damage signals, including those evoked by …