The transcription factor CREB? for'cyclic AMP response element-binding protein'? functions
in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in …

Migraine is a common, disabling, and undertreated episodic brain disorder that is more
common in women than in men. Unbiased genome-wide association studies have identified …

Migraine is the most common brain disorder, affecting approximately 14% of the adult
population, but its molecular mechanisms are poorly understood. We report the results of a …

First described 15 years ago as a cysteine-rich sequence that was common to a small group
of homeodomain transcription factors, the LIM domain is now recognized as a tandem zinc …

We present an analysis of the current foot-and-mouth disease epidemic in Great Britain over
the first 2 months of the spread of the virus. The net transmission potential of the pathogen …

The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

The perception of the Z-disc in striated muscle has undergone significant changes in the
past decade. Traditionally, the Z-disc has been viewed as a passive constituent of the …

During sarcomere contraction skeletal and cardiac muscle cells consume large amounts of
energy. To satisfy this demand, metabolic enzymes are associated with distinct regions of …

Early growth response-1 (Egr-1) is a Cys2-His2-type zinc-finger transcription factor. A broad
range of extracellular stimuli is capable of activating Egr-1, thus mediating growth …

MicroRNAs (miRNAs) are key post transcriptional regulators of their multiple target genes.
However, the detailed profile of miRNA expression in Parkinson's disease, the second most …