Extracellular matrix (ECM) derived components are emerging sources for the engineering of
biomaterials that are capable of inducing desirable cell-specific responses. This review …

Biomaterials based on natural materials including decellularized tissues and tissue-derived
hydrogels are becoming more widely used for clinical applications. Because of their native …

All vertebrates possess mechanisms to restore damaged tissues with outcomes ranging
from regeneration to scarring. Unfortunately, the mammalian response to tissue injury most …

Various modifications have been performed on biomaterials to improve their applications in
tissue engineering and regenerative medicine. However, the challenges of immunogenicity …

Each year, hundreds of thousands coronary bypass procedures are performed in the US, yet
there currently exists no off-the-shelf alternative to autologous vessel transplant. In the …

Fibroblasts are a major cell population that perform critical functions in the wound healing
process. In response to injury, they proliferate and migrate into the wound space, engaging …

Impaired wound healing is a major complication of diabetes, and despite the associated
risks, treatment strategies for diabetic wounds remain limited. This is due, in part, to an …

Decellularized biologic scaffolds are gaining popularity over synthetic biomaterials as
naturally derived materials capable of promoting improved healing. Nevertheless, the most …

Hydrogels composed of solubilized decellularized extracellular matrix (ECM) are attractive
materials because they combine the complexity of native ECM with injectability and ease of …

It has long been hypothesized that bleeding symptoms in people with hypermobility occur as
a result of abnormalities in the collagen of the vessel wall or the connective tissues. The …