Advanced nanotechnology leading the way to multimodal imaging‐guided precision surgical therapy

C Wang, W Fan, Z Zhang, Y Wen, L Xiong… - Advanced …, 2019 - Wiley Online Library
Surgical resection is the primary and most effective treatment for most patients with solid
tumors. However, patients suffer from postoperative recurrence and metastasis. In the past …

Optical imaging modalities: principles and applications in preclinical research and clinical settings

G Pirovano, S Roberts, S Kossatz… - Journal of Nuclear …, 2020 - Soc Nuclear Med
With the ability to noninvasively image and monitor molecular processes within tumors,
molecular imaging represents a fundamental tool for cancer scientists. In the current review …

Prospective testing of clinical Cerenkov luminescence imaging against standard-of-care nuclear imaging for tumour location

EC Pratt, M Skubal, B Mc Larney… - Nature biomedical …, 2022 - nature.com
In oncology, the feasibility of Cerenkov luminescence imaging (CLI) has been assessed by
imaging superficial lymph nodes in a few patients undergoing diagnostic 18F-fluoro-2 …

Molecularly generated light and its biomedical applications

C Ran, K Pu - Angewandte Chemie International Edition, 2024 - Wiley Online Library
Molecularly generated light, referred to here as “molecular light”, mainly includes
bioluminescence, chemiluminescence, and Cerenkov luminescence. Molecular light …

Advancements in Intraoperative Near-Infrared Fluorescence Imaging for Accurate Tumor Resection: A Promising Technique for Improved Surgical Outcomes and …

SK Rainu, RG Ramachandran… - ACS Biomaterials …, 2023 - ACS Publications
Clear surgical margins for solid tumor resection are essential for preventing cancer
recurrence and improving overall patient survival. Complete resection of tumors is often …

State-of-the-art challenges and emerging technologies in radiation detection for nuclear medicine imaging: A review

E Enlow, S Abbaszadeh - Frontiers in Physics, 2023 - frontiersin.org
Single photon emission computed tomography (SPECT) and positron emission tomography
(PET) are established medical imaging modalities that have been implemented for decades …

Imaging of fibroblast activation protein alpha expression in a preclinical mouse model of glioma using positron emission tomography

DN Pandya, A Sinha, H Yuan, L Mutkus, K Stumpf… - Molecules, 2020 - mdpi.com
Glioblastoma multiforme (GBM) is the most aggressive glioma of the primary central nervous
system. Due to the lack of effective treatment options, the prognosis for patients remains …

Can intraoperative fluorescence imaging identify all lesions while the road map created by preoperative nuclear imaging is masked?

P Meershoek, T Buckle, MN van Oosterom… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Tracers can help visualize the lymphatic drainage patterns and sentinel nodes (SNs) of
individual prostate cancer patients. To determine the role of nuclear medicine in surgical …

Detection of shortwave-infrared Cerenkov luminescence from medical isotopes

BE Mc Larney, Q Zhang, EC Pratt… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Medical radioisotopes produce Cerenkov luminescence (CL) from charged subatomic
particles (β+/−) traveling faster than light in dielectric media (eg, tissue). CL is a blue …

Cerenkov radiation shining a light for cancer theranostics

M Teng, X Liang, H Liu, Z Li, X Gao, C Zhang, H Cheng… - Nano Today, 2024 - Elsevier
Cerenkov radiation (CR), a phenomenon where charged particles traveling through a
medium exceed the speed of light, has gained increasing attention in the realm of health …