Human adenoviruses (HAdVs) are an important cause of infections in both
immunocompetent and immunocompromised individuals, and they continue to provide …

To thwart viral infection, the host has developed a formidable and integrated defense
network that comprises our innate and adaptive immune response. In recent years, it has …

This review describes the diverse array of pathways and molecular targets that are used by
viruses to elude immune detection and destruction. These include targeting of pathways for …

Replication-deficient human adenovirus type 5 (Ad5) can be produced to high titers in
complementing cell lines, such as PER. C6, and is widely used as a vaccine and gene …

Human adenoviruses are the most widely used vectors in gene medicine, with applications
ranging from oncolytic therapies to vaccinations, but adenovirus vectors are not without side …

Adenovirus (Ad) infections in immunocompromised hosts have increased in frequency as
the number of patients with transplants of bone marrow, liver, kidney, heart and other organs …

Cellular BCL-2-related proteins (cBCL-2s) function as regulators of programmed cell death
(apoptosis), in part by modulating the release of proapoptotic signaling molecules from …

Adenovirus is increasingly being recognised as a significant pathogen in children following
bone marrow transplantation. The virus is endemic in the general paediatric population, and …

In the evolutionary battle between viruses and their hosts, viruses have armed themselves
with weapons to defeat the host's attacks on infected cells. Various proteins encoded in the …

Most of the early gene therapy trials for cystic fibrosis have been with adenovirus vectors.
First-generation viruses with E1a and E1b deleted are limited by transient expression of the …