The placenta is essential for normal in utero development in mammals. In humans, defective
placental formation underpins common pregnancy disorders such as pre-eclampsia and …

The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

Trophoblasts are extraembryonic cells that are essential for maintaining pregnancy. Human
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation …

We recently derived mouse expanded potential stem cells (EPSCs) from individual
blastomeres by inhibiting the critical molecular pathways that predispose their differentiation …

Classic embryological experiments have established that the early mouse embryo develops
via sequential lineage bifurcations. The first segregated lineage is the trophectoderm …

Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell
fate decisions during pre-implantation development, but their lineage potential remains …

In primates, the amnion emerges through cavitation of the epiblast during implantation,
whereas in other species it does so later at gastrulation by the folding of the ectoderm. How …

Stem cells self-renew and generate specialized progeny through differentiation, but vary in
the range of cells and tissues they generate, a property called developmental potency …

Background Human pluripotent stem cells offer the best available model to study the
underlying cellular and molecular mechanisms of human embryonic lineage specification …

Human trophoblast stem cells (hTSCs) provide a valuable model to study placental
development and function. While primary hTSCs have been derived from embryos/early …