Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections

Q Xie, Q Li, H Fang, R Zhang, H Tang… - Clinical Reviews in Allergy …, 2024 - Springer
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, modulate
immune cell functions, particularly macrophages. This review explores the potential …

Hospital Acquired Sepsis, Disease Prevalence, and Recent Advances in Sepsis Mitigation

M Garvey - Pathogens, 2024 - mdpi.com
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection, commonly associated with nosocomial transmission. Gram-negative bacterial …

Co-Delivery of a High Dose of Amphotericin B and Itraconazole by Means of a Dry Powder Inhaler Formulation for the Treatment of Severe Fungal Pulmonary …

SS Celi, R Fernández-García, AI Afonso-Urich… - Pharmaceutics, 2023 - mdpi.com
Over the past few decades, there has been a considerable rise in the incidence and
prevalence of pulmonary fungal infections, creating a global health problem due to a lack of …

Circulatory Inflammatory Proteins as Early Diagnostic Biomarkers for Invasive Aspergillosis in Patients with Hematologic Malignancies—an Exploratory Study

R Aerts, I Ricaño-Ponce, M Bruno, T Mercier, D Rosati… - Mycopathologia, 2024 - Springer
Objectives Invasive aspergillosis (IA) is a major cause of mortality in immunocompromised
patients and it is difficult to diagnose because of the lack of reliable highly sensitive …

Risk of Invasive Fungal Infections in Patients With Chronic Lymphocytic Leukemia Treated With Bruton Tyrosine Kinase Inhibitors: A Case-Control Propensity Score …

NI Agudelo Higuita, DB Chastain, B Scott… - Open Forum …, 2024 - academic.oup.com
Background Prior reports have suggested a possible increase in the frequency of invasive
fungal infections (IFIs) with use of a Bruton tyrosine kinase inhibitor (BTKi) for treatment of …

A retrospective Italian analysis on the characteristics of invasive fungal infections in the intensive care unit setting: CHARTER‐IFI study

PL Viale, S Mirandola, C Natalini, LD Esposti… - Mycoses, 2024 - Wiley Online Library
Background Invasive fungal infections (IFI), prevalent in critically ill ICU patients, have
gained attention due to post‐COVID‐19 epidemiological shifts. Notably, COVID‐19 …

Glucocorticoids as a risk factor for infection and adverse outcomes in non‐HIV and non‐transplant patients with cryptococcal meningitis

L Kim, C Ferraz, MF Corbisiero, S Gorvetzian… - Mycoses, 2024 - Wiley Online Library
Background Cryptococcal meningitis (CM), an opportunistic fungal infection affecting
immunocompromised hosts, leads to high mortality. The role of previous exposure to …

Development of a Prognostic Nomogram for Nonneutropenic Invasive Pulmonary Aspergillosis Based on Machine Learning

W Du, W Ji, T Luo, Y Zhang, W Guo… - Journal of Inflammation …, 2024 - Taylor & Francis
Background The incidence of invasive pulmonary aspergillosis (IPA) is progressively rising
in the nonneutropenic population, but studies investigating relevant prognostic factors …

[HTML][HTML] Refractory fungal infection: Three case reports highlighting good practice

R Barnes, DA Enoch, W Ingram, J Martin, J Clay… - Medical Mycology Case …, 2024 - Elsevier
Refractory invasive fungal infection is a significant clinical problem, with high morbidity,
mortality and costs. The complex causes of refractory infection include breakthrough …

Positive Toxoplasma IgG Serology Is Associated with Increased Overall Mortality-A Propensity Score-Matched Analysis.

G Montalbano, VM Kung… - The American Journal …, 2023 - europepmc.org
Toxoplasma gondii is a prevalent parasitic disease with significant morbidity and mortality in
immunocompromised populations. We lack long-term outcomes for latent infections. We …