The endocannabinoid system: a potential target for the treatment of various diseases

H Lowe, N Toyang, B Steele, J Bryant… - International journal of …, 2021 - mdpi.com
The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

Bioactive lipids, inflammation and chronic diseases

A Leuti, D Fazio, M Fava, A Piccoli, S Oddi… - Advanced Drug Delivery …, 2020 - Elsevier
Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Endocannabinoid signaling at the periphery: 50 years after THC

M Maccarrone, I Bab, T Bíró, GA Cabral, SK Dey… - Trends in …, 2015 - cell.com
In 1964, the psychoactive ingredient of Cannabis sativa, Δ 9-tetrahydrocannabinol (THC),
was isolated. Nearly 30 years later the endogenous counterparts of THC, collectively termed …

Endocannabinoids—at the crossroads between the gut microbiota and host metabolism

PD Cani, H Plovier, M Van Hul, L Geurts… - Nature Reviews …, 2016 - nature.com
Various metabolic disorders are associated with changes in inflammatory tone. Among the
latest advances in the metabolism field, the discovery that gut microorganisms have a major …

Cannabinoids and cytochrome P450 interactions

O Zendulka, G Dovrtelova, K Nosková… - Current drug …, 2016 - ingentaconnect.com
Objective: This review consists of three parts, representing three different possibilities of
interactions between cannabinoid receptor ligands of both exogenous and endogenous …

Developmental origins of NAFLD: a womb with a clue

SR Wesolowski, KCE Kasmi, KR Jonscher… - Nature reviews …, 2017 - nature.com
Abstract Changes in the maternal environment leading to an altered intrauterine milieu can
result in subtle insults to the fetus, promoting increased lifetime disease risk and/or disease …

Endocannabinoid system components as potential biomarkers in psychiatry

F Navarrete, MS García-Gutiérrez… - Frontiers in …, 2020 - frontiersin.org
The high heterogeneity of psychiatric disorders leads to a lack of diagnostic precision.
Therefore, the search of biomarkers is a fundamental aspect in psychiatry to reach a more …

Metabolism of the endocannabinoid anandamide: open questions after 25 years

M Maccarrone - Frontiers in molecular neuroscience, 2017 - frontiersin.org
Cannabis extracts have been used for centuries, but its main active principle∆ 9-
tetrahydrocannabinol (THC) was identified about 50 years ago. Yet, it is only 25 years ago …

A guide to targeting the endocannabinoid system in drug design

A Stasiulewicz, K Znajdek, M Grudzień… - International journal of …, 2020 - mdpi.com
The endocannabinoid system (ECS) is one of the most crucial systems in the human
organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of …

The role of the endocannabinoid system in female reproductive tissues

OLS Walker, AC Holloway, S Raha - Journal of ovarian research, 2019 - Springer
There has been increasing interest in the role of endocannabinoids as critical modulators of
the female reproductive processes. Endocannabinoids are natural ligands of cannabinoid …