The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …

Nucleoli are multicomponent condensates defined by coexisting sub-phases. We identified
distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks …

Phase separation and percolation contribute to phase transitions of multivalent
macromolecules. Contributions of percolation are evident through the viscoelasticity of …

Phase separation in aqueous solutions of macromolecules underlies the generation of
biomolecular condensates in cells. Condensates are membraneless bodies, representing …

Liquid-liquid phase separation (LLPS) facilitates the formation of membraneless organelles
within cells, with implications in various biological processes and disease states. AT-rich …

In eukaryotic genomes, transcriptional machinery and nucleosomes compete for binding to
DNA sequences; thus, a crucial aspect of gene regulatory element function is to modulate …

Abstract Histone-lysine N-methyltransferase 2 (KMT2) methyltransferases play critical roles
in gene regulation, cell differentiation, animal development, and human diseases. KMT2 …

Phase separation (PS) drives the formation of biomolecular condensates that are emerging
biological structures involved in diverse cellular processes. Recent studies have unveiled …

Nuclear compartments form via biomolecular phase separation, mediated through
multivalent properties of biomolecules concentrated within condensates. Certain …