Comparative genome analyses reveal that organismal complexity scales not with gene
number but with gene regulation. Recent efforts indicate that the human genome likely …

Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …

Transcription and translation are two main pillars of gene expression. Due to the different
timings, spots of action, and mechanisms of regulation, these processes are mainly …

Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The
balance between mRNA synthesis and decay determines these levels. We demonstrate that …

The SAGA (Spt–Ada–Gcn5 acetyltransferase) coactivator complex contains distinct
chromatin-modifying activities and is recruited by DNA-bound activators to regulate the …

Translation elongation factor eEF1A has a well-defined role in protein synthesis. In this
study, we demonstrate a new role for eEF1A: it participates in the entire process of the heat …

RNA is the fundamental information transfer system in the cell. The ability to follow single
messenger RNAs (mRNAs) from transcription to degradation with fluorescent probes gives …

Transcript buffering involves reciprocal adjustments between overall rates in mRNA
synthesis and degradation to maintain similar cellular concentrations of mRNAs. This …

OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is
amplified in a subset of tumours and overexpressed in most cases of group 3 and group 4 …

Recent advancements in single-cell and single-molecule imaging technologies have
resolved biological processes in time and space that are fundamental to understanding the …