The monovalent methyl group is derived from methane through the removal of a hydrogen
atom, 1 and its etymology is directly related to the discovery of methanol. 2 The first reports …

Information on drug absorption and disposition in infants and children has increased
considerably over the past 2 decades. However, the impact of specific age-related effects on …

Growth and development can be investigated using readily observable demographic factors
such as weight and age. Size is the primary covariate and can be referenced to a 70-kg …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

The principles of inter‐species dose extrapolation are poorly understood and applied. We
provide an overview of the principles underlying dose scaling for size and dose adjustment …

Background Prediction of the exposure of neonates, infants and children to xenobiotics is
likely to be more successful using physiologically based pharmacokinetic models than …

The approach to paediatric drug dosing needs to be based on the physiological
characteristics of the child and the pharmacokinetic parameters of the drug. This review …

Profound changes in drug metabolizing enzyme (DME) expression occurs during
development that impacts the risk of adverse drug events in the fetus and child. A review of …

Background Clinical trials in children are being encouraged by regulatory authorities in light
of the immense off-label and unlicensed use of drugs in the paediatric population. The use …

A diversity of equations is available for the estimation of liver volume (LV), derived from
studies in populations of ethnically homogeneous individuals and using a variety of methods …