Research on psoriasis pathogenesis has largely increased knowledge on skin biology in
general. In the past 15 years, breakthroughs in the understanding of the pathogenesis of …

Psoriasis is a complex, chronic relapsing and inflammatory skin disorder with a prevalence
of approximately 2% in the general population worldwide. Psoriasis can be triggered by …

The skin barrier is broadly composed of two elements—a physical barrier mostly localised in
the epidermis, and an immune barrier localised in both the dermis and epidermis. These two …

Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been
profoundly revised following recent advances in the understanding of its pathophysiology. In …

Psoriasis is a common T-cell-mediated skin disease with 2–3% prevalence worldwide.
Psoriasis is considered to be an autoimmune disease, but the precise nature of the …

Psoriasis is a chronic inflammatory autoimmune disease characterized by an excessively
aberrant hyperproliferation of keratinocytes. The pathogenesis of psoriasis is complex and …

Highlights•Plaque psoriasis exhibits both autoimmune and autoinflammatory immune
responses.•The autoinflammatory loop in psoriasis is driven by IL-36 cytokine responses.• …

A variety of mechanisms have been suggested as the means by which infections can initiate
and/or exacerbate autoimmune diseases. One mechanism is molecular mimicry, where a …

Psoriasis is a chronic inflammatory skin disease associated with a T helper 17 response.
Yet, it has proved challenging to identify relevant peptide-based T cell antigens. Antigen …

Psoriasis is one of the most common immune-mediated chronic, inflammatory skin diseases
characterized by hyperproliferative keratinocytes and infiltration of T cells, dendritic cells …