The authors present a systematic review of the informed consent literature that focuses on
better understanding barriers to change within the research practice. The author also …

When researchers attempt to answer clinical questions, they must first decide whether to
observe the events taking place in the subjects (observational study) or to introduce an …

AIMS: To determine the number of patients needed to be screened (NNS) and allocated
(NNA) in order to include one participant in a randomized clinical trial (RCT), and to …

Background There is substantial need to rigorously evaluate existing and new therapies for
pulmonary arterial hypertension (PAH) and other severe and relatively rare conditions …

Background: Despite the high incidence of acute stroke, only a minority of patients are
enrolled in acute stroke treatment trials. We aimed to identify factors associated with …

OBJECTIVE: The Tumor Board (TB) allows for an interdisciplinary approach to cancer
treatment designed to encourage evidence-based treatment. However, its role in facilitating …

Background: Patients with symptomatic recalcitrant thumb carpometacarpal arthritis often
undergo surgery. Although most surgical patients do well, the authors anticipated that a …

Background To promote equitable recruitment for studies conducted in the inpatient hospital
setting, we sought to characterize reasons why individuals, both from historically minoritized …

The term'therapeutic misconception'(TM) was introduced in 1982 to conceptualize how
some psychiatry trial participants perceived and interpreted their involvement in research …

Objectives: Aneurysmal subarachnoid hemorrhage (SAH) is a devastating disorder that still
requires much clinical study. However, the decision to participate in a randomized clinical …