Malaria is a leading cause of mortality and morbidity globally, and effective vaccines are
urgently needed. Malaria vaccine approaches can be broadly grouped as pre‐erythrocytic …

Seventeen million people die of transmittable diseases and 2/3 of the world's population
suffer them annually. Malaria, tuberculosis, AIDS, hepatitis, and reemerging and new …

Immunization is one of the great advances in public health. Figure 0.1 shows a camel with a
solar-powered refrigerator on his back carrying vaccines across a hot desert to the far …

Summary Background RTS, S/AS02 is a pre-erythrocytic malaria vaccine based on the
circumsporozoite surface protein of Plasmodium falciparum fused to HBsAg, incorporating a …

Effective, safe antimalarial vaccines have proved elusive. The synthetic polypeptide SPf66
vaccine is based on pre-erythrocytic and asexual blood-stage proteins of Plasmodium …

SPf66 malaria vaccine is a synthetic protein with aminoacid sequences derived from pre-
erythrocytic and asexual blood-stage proteins of Plasmodium falciparum. SPf66 was found …

In the first phase III efficacy trial of the malaria vaccine SPf66 in Africa, MOIs in SPf66-and
placebo-vaccinated children were analyzed by polymerase chain reaction-restriction …

The highly attenuated NYVAC vaccinia virus strain has been utilized to develop a
multiantigen, multistage vaccine candidate for malaria, a disease that remains a serious …

Dedicated to the memory of Professors Henry G. Kunkel and Bruce Merrifield (Rockefeller
University, New York), who introduced us to the fascinating worlds of immunology and …

Background A malaria vaccine is badly needed. SPf66 was one of the earliest vaccines
developed. It is a synthetic peptide vaccine containing antigens from the blood stages of …