Engineering precise sequence-defined polymers for advanced functions

Q Shi, Z Deng, M Hou, X Hu, S Liu - Progress in Polymer Science, 2023 - Elsevier
Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …

Unnatural helical peptidic foldamers as protein segment mimics

P Sang, J Cai - Chemical Society Reviews, 2023 - pubs.rsc.org
Unnatural helical peptidic foldamers have attracted considerable attention owing to their
unique folding behaviours, diverse artificial protein binding mechanisms, and promising …

Advances in development of antimicrobial peptidomimetics as potential drugs

N Molchanova, PR Hansen, H Franzyk - Molecules, 2017 - mdpi.com
The rapid emergence of multidrug-resistant pathogens has evolved into a global health
problem as current treatment options are failing for infections caused by pan-resistant …

Sequence-defined synthetic polymers for new-generation functional biomaterials

Z Deng, Q Shi, J Tan, J Hu, S Liu - ACS Materials Letters, 2021 - ACS Publications
Synthetic polymers have been extensively exploited for biomedical and pharmacological
applications, spanning from surgical devices, diagnostics, tissue engineering, regenerative …

Novel antimicrobial peptides modified with fluorinated sulfono-γ-AA having high stability and targeting multidrug-resistant bacteria infections

X Guo, X Miao, Y An, T Yan, Y Jia, B Deng, J Cai… - European Journal of …, 2024 - Elsevier
The emergence and increasing prevalence of multidrug-resistant (MDR) bacteria have
posed an urgent demand for novel antibacterial drugs. Currently, antimicrobial peptides …

Natural antifungal peptides/proteins as model for novel food preservatives

T Thery, KM Lynch, EK Arendt - … in food science and food safety, 2019 - Wiley Online Library
A large range of ingredients for food and food products are subject to fungal contamination,
which is a major cause of destruction of crops, exposure of animals and humans to invasive …

Polycarbonates with potent and selective antimicrobial activity toward gram-positive bacteria

A Nimmagadda, X Liu, P Teng, M Su, Y Li… - …, 2017 - ACS Publications
The resistance developed by life-threatening bacteria toward conventional antibiotics has
become a major concern in public health. To combat antibiotic resistance, there has been a …

Amino sulfonic acids, peptidosulfonamides and other related compounds

OO Grygorenko, AV Biitseva, S Zhersh - Tetrahedron, 2018 - Elsevier
A review with 636 references. The literature on saturated amino sulfonic acids with
primary/secondary amino group and their derivatives from XIX century to 2016 is surveyed …

Sequence-defined backbone modifications regulate antibacterial activity of oligoTEAs

M Porel, DN Thornlow, CM Artim… - ACS chemical biology, 2017 - ACS Publications
In response to the urgent need for new antibiotic development strategies, antimicrobial
peptides (AMPs) and other synthetic polymers are being actively investigated as promising …

Rational Design of Dimeric Lysine N-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents

Y Niu, M Wang, Y Cao, A Nimmagadda… - Journal of Medicinal …, 2018 - ACS Publications
Antibiotic resistance is one of the biggest threats to public health, and new antibacterial
agents hence are in an urgent need to combat infectious diseases caused by multidrug …