Collagen hydrogels are among​ the most well-studied platforms for drug delivery and in situ
tissue engineering, thanks to their low cost, low immunogenicity, versatility, biocompatibility …

Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

The central nervous system (CNS), consisting of the brain, spinal cord, and retina,
superintends to the acquisition, integration and processing of peripheral information to …

More than a century ago, it was proposed that mechanical forces could drive tissue
formation. However, only recently with the advent of enabling biophysical and molecular …

Although biochemical signals that modulate stem cell self-renewal and differentiation were
extensively studied, only recently were the mechanical properties of a stem cell's …

Peripheral nerve injury is a common clinical entity, which may arise due to traumatic,
tumorous, or even iatrogenic injury in craniomaxillofacial surgery. Despite advances in …

Background A number of adhesion-mediated signaling pathways and cell-cycle events have
been identified that regulate cell proliferation, yet studies to date have been unable to …

The cellular environment impacts a myriad of cellular functions by providing signals that can
modulate cell phenotype and function. Physical cues such as topography, roughness …

Biological cells are well known to respond to a multitude of chemical signals. In the nervous
system, chemical signaling has been shown to be crucially involved in development, normal …

Spinal cord injury (SCI) presents a complex regenerative problem due to the multiple facets
of growth inhibition that occur following trauma to the cord parenchyma and stroma …