The TNF–TNFR family of co-signal molecules
T So, N Ishii - Co-signal Molecules in T Cell Activation: Immune …, 2019 - Springer
Costimulatory signals initiated by the interaction between the tumor necrosis factor (TNF)
ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion …
ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion …
[HTML][HTML] TL1A (TNFSF15) and DR3 (TNFRSF25): a co-stimulatory system of cytokines with diverse functions in gut mucosal immunity
TL1A and its functional receptor DR3 are members of the TNF/TNFR superfamilies of
proteins. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals …
proteins. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals …
The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells
The tumor necrosis factor (TNF)-family cytokine TL1A (TNFSF15) costimulates T cells and
promotes diverse T cell-dependent models of autoimmune disease through its receptor …
promotes diverse T cell-dependent models of autoimmune disease through its receptor …
Structural determinants of DISC function: new insights into death receptor-mediated apoptosis signalling
Death receptors are members of the tumour necrosis factor (TNF) receptor superfamily
characterised by an~ 80 amino acid long alpha-helical fold, termed the death domain (DD) …
characterised by an~ 80 amino acid long alpha-helical fold, termed the death domain (DD) …
The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9 …
AC Richard, C Tan, ET Hawley… - The Journal of …, 2015 - journals.aai.org
The TNF family cytokine TL1A (Tnfsf15) costimulates T cells and type 2 innate lymphocytes
(ILC2) through its receptor DR3 (Tnfrsf25). DR3-deficient mice have reduced T cell …
(ILC2) through its receptor DR3 (Tnfrsf25). DR3-deficient mice have reduced T cell …
Progranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity
C Liu, XX Li, W Gao, W Liu, DS Liu - PloS one, 2014 - journals.plos.org
Atsttrin, a progranulin (PGRN)-derived molecule composed of three TNFR-binding domains
of PGRN, binds to TNF receptors (TNFR) and is therapeutic against inflammatory arthritis …
of PGRN, binds to TNF receptors (TNFR) and is therapeutic against inflammatory arthritis …
The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator
Originally described in 2002 as a T cell-costimulatory cytokine, the tumor necrosis factor
family member TNF-like factor 1A (TL1A), encoded by the TNFSF15 gene, has since been …
family member TNF-like factor 1A (TL1A), encoded by the TNFSF15 gene, has since been …
The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection
Innate immunity is regulated by cholinergic signalling through nicotinic acetylcholine
receptors. We show here that signalling through the M3 muscarinic acetylcholine receptor …
receptors. We show here that signalling through the M3 muscarinic acetylcholine receptor …
Membrane trafficking of death receptors: implications on signalling
W Schneider-Brachert, U Heigl… - International journal of …, 2013 - mdpi.com
Death receptors were initially recognised as potent inducers of apoptotic cell death and
soon ambitious attempts were made to exploit selective ignition of controlled cellular suicide …
soon ambitious attempts were made to exploit selective ignition of controlled cellular suicide …
[HTML][HTML] The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity
JP Twohig, M Marsden, SM Cuff… - … : official publication of …, 2012 - ncbi.nlm.nih.gov
Abstract Death receptor 3 (DR3, TNFRSF25), the closest family relative to tumor necrosis
factor receptor 1, promotes CD4+ T-cell-driven inflammatory disease. We investigated the in …
factor receptor 1, promotes CD4+ T-cell-driven inflammatory disease. We investigated the in …