Mutation-induced activation of WNT–β-catenin signalling is a frequent driver event in human
cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained …

Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …

Wnt signaling has multiple functions beyond the transcriptional effects of β-catenin
stabilization. We review recent investigations that uncover new cell physiological effects …

Cancer is one of the greatest public health challenges. According to the World Health
Organization (WHO), 9.6 million cancer deaths have been reported in 2018. The most …

R-spondin (RSPO) proteins constitute a family of four secreted glycoproteins (RSPO1–4)
that have appeared as multipotent signaling ligands. The best-known molecular function of …

Skeletal dysplasias are a diverse group of heritable diseases affecting bone and cartilage
growth. Throughout the years, the molecular defect underlying many of the diseases has …

It is well established that mutations in the canonical WNT-signalling pathway play a major
role in various cancers. Critical to developing new therapeutic strategies is understanding …

Among human tumorigenic viruses, the role of Human papillomavirus (HPV) has been
proven as one of the most important oncoviruses that are associated with a large number of …

Proteolysis-targeting chimeras (PROTACs) are an emerging technology for therapeutic
intervention, but options to target cell surface proteins and receptors remain limited. Here we …

RNF43 is an E3 ligase that inhibits Wnt signaling by ubiquitinating Wnt receptors for
degradation. It is mutated in various cancer types with the most recurrent mutation being the …