Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

Pyk2 is a non-receptor tyrosine kinase highly enriched in forebrain neurons. Pyk2 is closely
related to focal adhesion kinase (FAK), which plays an important role in sensing cell …

Alzheimer's disease is a global public health problem and the most common form of
dementia. Due to the failure of many single therapies targeting the two hallmarks, Aβ and …

Abstract STEP (STriatal-Enriched Protein Tyrosine Phosphatase) is a brain-specific
phosphatase that plays an important role in controlling signaling molecules involved in …

The burden of Alzheimer's disease, the most prevalent neurodegenerative disease, is
increasing exponentially due to the increase in the elderly population worldwide. Synaptic …

STriatal-Enriched protein tyrosine Phosphatase (STEP) is a tyrosine phosphatase that has
been implicated in Alzheimer's disease (AD), the most common form of dementia, and many …

A significant proportion of brains with Alzheimer's disease pathology are obtained from
patients that were cognitively normal, suggesting that differences within the brains of these …

Cognitive impairment is one of the most common symptoms of hepatic encephalopathy (HE).
However, there is a lack of easily implementable rehabilitation strategies. As an easy-to …

Autism spectrum disorders (ASDs) are highly prevalent childhood illnesses characterized by
impairments in communication, social behavior, and repetitive behaviors. Studies have …

Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific enzyme that
regulates the signaling molecules that control synaptic plasticity and neuronal function …