Recent studies suggest that vortex ring formation during left ventricular (LV) rapid filling is an
optimized mechanism for blood transport, and that the volume of the vortex ring is an …

Despite Leonardo da Vinci's observation (circa 1511) that “the atria or filling chambers
contract together while the pumping chambers or ventricles are relaxing and vice versa,” the …

Finite stress and strain analyses of the heart provide insight into the biomechanics of
myocardial function and dysfunction. Herein, we describe progress toward dynamic patient …

Simulations of cardiac electrophysiology and mechanics have been reported to be sensitive
to the microstructural anisotropy of the myocardium. Consequently, a personalized …

Background Whereas ventricular filling has been extensively studied and debated, atrial
filling is less well characterized. Therefore, the aim of this study was to quantify atrial filling …

To describe left ventricular (LV) function comprehensively, it is crucial to characterize
precisely transmitral, intraventricular and transaortic pressure–flow relations. The site of …

We investigated the determinants of ventricular early diastolic lengthening and mechanics of
suction using a mathematical model of the left ventricle (LV). The model was based on a …

Viscosity is proposed to modulate diastolic function, but only limited understanding of the
source (s) of viscosity exists. In vitro experiments have shown that the proline-glutamic acid …

In cardiovascular research, relaxation and stiffness are calculated from pressure-volume
(PV) curves by separately fitting the data during the isovolumic and end-diastolic phases …

Titin exhibits an interaction between its PEVK segment and the actin filament resulting in
viscosity, a speed dependent resistive force, which significantly influences diastolic filling in …