Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …

Type 1 and 2 diabetes mellitus: A review on current treatment approach and gene therapy as potential intervention

SY Tan, JLM Wong, YJ Sim, SS Wong… - Diabetes & metabolic …, 2019 - Elsevier
Type 1 and type 2 diabetes mellitus is a serious and lifelong condition commonly
characterised by abnormally elevated blood glucose levels due to a failure in insulin …

Regenerative capacity of adipose derived stem cells (ADSCs), comparison with mesenchymal stem cells (MSCs)

L Mazini, L Rochette, M Amine, G Malka - International journal of …, 2019 - mdpi.com
Adipose tissue is now on the top one of stem cell sources regarding its accessibility,
abundance, and less painful collection procedure when compared to other sources. The …

Mesenchymal stem cells and immunomodulation: current status and future prospects

F Gao, SM Chiu, DAL Motan, Z Zhang, L Chen… - Cell death & …, 2016 - nature.com
The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …

Allogeneic bone marrow–derived mesenchymal stromal cells for hepatitis B virus–related acute‐on‐chronic liver failure: a randomized controlled trial

B Lin, J Chen, W Qiu, K Wang, D Xie, X Chen… - …, 2017 - Wiley Online Library
Mortality from hepatitis B virus (HBV)–related acute‐on‐chronic liver failure (ACLF) is high
due to limited treatment options. Preclinical and clinical investigations have proved that …

Stem cell-based clinical trials for diabetes mellitus

E De Klerk, M Hebrok - Frontiers in endocrinology, 2021 - frontiersin.org
Since its introduction more than twenty years ago, intraportal allogeneic cadaveric islet
transplantation has been shown to be a promising therapy for patients with Type I Diabetes …

Identifying the therapeutic significance of mesenchymal stem cells

VK Mishra, HH Shih, F Parveen, D Lenzen, E Ito… - Cells, 2020 - mdpi.com
The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due
to their immense potential for immunosuppression and their therapeutic role in immune …

Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T …

A Ribeiro, P Laranjeira, S Mendes, I Velada… - Stem cell research & …, 2013 - Springer
Introduction The ability to self-renew, be easily expanded in vitro and differentiate into
different mesenchymal tissues, render mesenchymal stem cells (MSCs) an attractive …

Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: identification of a novel role in improving insulin sensitivity

Y Si, Y Zhao, H Hao, J Liu, Y Guo, Y Mu, J Shen… - Diabetes, 2012 - Am Diabetes Assoc
Infusion of mesenchymal stem cells (MSCs) has been shown to effectively lower blood
glucose in diabetic individuals, but the mechanism involved could not be adequately …

Immunomodulatory properties of mesenchymal stem cells and their therapeutic applications

TG Yi, SU Song - Archives of pharmacal research, 2012 - Springer
Mesenchymal stem cells (MSCs) are adult stem cells that can be isolated from most adult
tissues, including bone marrow, adipose, liver, amniotic fluid, lung, skeletal muscle and …