The p38/MKP-1 signaling axis in oral cancer: Impact of tumor-associated macrophages

Z Li, F Liu, KL Kirkwood - Oral oncology, 2020 - Elsevier
Oral squamous cell carcinomas (OSCC) constitute over 95% of all head and neck
malignancies. As a key component of the tumor microenvironment (TME), chronic …

The tristetraprolin family of RNA-binding proteins in cancer: progress and future prospects

Y Saini, J Chen, S Patial - Cancers, 2020 - mdpi.com
Post-transcriptional regulation of gene expression plays a key role in cellular proliferation,
differentiation, migration, and apoptosis. Increasing evidence suggests dysregulated post …

Galanin modulates the neural niche to favour perineural invasion in head and neck cancer

CS Scanlon, R Banerjee, RC Inglehart, M Liu… - Nature …, 2015 - nature.com
Perineural invasion (PNI) is an indicator of poor survival in multiple cancers. Unfortunately,
there is no targeted treatment for PNI since the molecular mechanisms are largely unknown …

Important cells and factors from tumor microenvironment participated in perineural invasion

Z Chen, Y Fang, W Jiang - Cancers, 2023 - mdpi.com
Simple Summary Perineural invasion (PNI) as the fourth way for solid tumor metastasis and
invasion has attracted a lot of attention, and axon growth and possible nerve “invasion” to …

Roles of tristetraprolin in tumorigenesis

JM Park, TH Lee, TH Kang - International journal of molecular sciences, 2018 - mdpi.com
Genetic loss or mutations in tumor suppressor genes promote tumorigenesis. The
prospective tumor suppressor tristetraprolin (TTP) has been shown to negatively regulate …

MAPK signaling pathway in oral squamous cell carcinoma: biological function and targeted therapy

Y Cheng, J Chen, Y Shi, X Fang, Z Tang - Cancers, 2022 - mdpi.com
Simple Summary The aim of the present review was to summarize our studies on the
signaling pathways in cancer types that are involved in the development of oral cancer and …

The galaninergic system: A target for cancer treatment

ML Sánchez, R Coveñas - Cancers, 2022 - mdpi.com
Simple Summary Peptidergic systems play an important role in cancer progression. The
galaninergic system (the peptide galanin and its receptors: galanin 1, 2 and 3) is involved in …

CD90 determined two subpopulations of glioma-associated mesenchymal stem cells with different roles in tumour progression

Q Zhang, DY Yi, BZ Xue, WW Wen, YP Lu… - Cell Death & …, 2018 - nature.com
Human glioma-associated mesenchymal stem cells (gbMSCs) are the stromal cell
components that contribute to the tumourigenesis of malignant gliomas. Recent studies have …

[HTML][HTML] The chick chorioallantoic membrane in vivo model to assess perineural invasion in head and neck cancer

LB Schmitd, M Liu, CS Scanlon… - Journal of …, 2019 - pmc.ncbi.nlm.nih.gov
Perineural invasion is a phenotype in which cancer surrounds or invades the nerves. It is
associated with poor clinical outcome for head and neck squamous cell carcinoma and …

[HTML][HTML] Agonists of galanin subtype 2 receptor may prevent pancreatic cancer and agonists of angiotensin II type 2 receptor may prevent colorectal cancer

GN Moll - European Journal of Pharmacology, 2024 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) remains a dreadful disease with poor prognosis.
While the prognosis of colorectal carcinoma (CRC) is better than that of PDAC, it still is the …