Quinoxaline Moiety: A Potential Scaffold against Mycobacterium tuberculosis

M Montana, V Montero, O Khoumeri, P Vanelle - Molecules, 2021 - mdpi.com
Background. The past decades have seen numerous efforts to develop new antitubercular
agents. Currently, the available regimens are lengthy, only partially effective, and associated …

An appraisal on synthetic and pharmaceutical perspectives of quinoxaline 1,4‐di‐N‐oxide scaffold

N Agrawal, A Bhardwaj - Chemical Biology & Drug Design, 2022 - Wiley Online Library
Abstract Quinoxaline 1, 4‐di‐N‐oxides (QdNOs) exhibit multifaceted biological properties,
wherein antimicrobial, anticancer, antitrypanosomal, and anti‐inflammatory properties are …

In Vitro and In Silico Analysis of New n-Butyl and Isobutyl Quinoxaline-7-carboxylate 1,4-di-N-oxide Derivatives against Trypanosoma cruzi as Trypanothione …

A González-González, O Sánchez-Sánchez… - International Journal of …, 2022 - mdpi.com
American trypanosomiasis is a worldwide health problem that requires attention due to
ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1 …

Synthesis of novel quinoxaline-alkynyl derivatives and their anti-Mycobacterium tuberculosis activity

LA Raphoko, K Lekgau, CM Lebepe, TC Leboho… - Bioorganic & Medicinal …, 2021 - Elsevier
The study report on the synthesis of a series of novel quinoxaline-alkynyl derivatives that
were evaluated for their activity against Mycobacterium tuberculosis (Mtb) H 37 RV strain. A …

Quinoxaline 1,4-di-N-oxides: a review of the importance of their structure in the development of drugs against infectious diseases and cancer

S Leyva-Ramos, A Pedraza-Alvarez - Medicinal Chemistry Research, 2021 - Springer
Abstract Quinoxaline 1, 4-di-N-oxides (QdNO's) are potent drugs used since the middle of
the last century as food additives to improve animal growth; however, their use as …

Comprehensive review on versatile pharmacology of quinoxaline derivative

V Bala Aakash, N Ramalakshmi… - Russian Journal of …, 2022 - Springer
Quinoxaline is a nitrogen-containing heterocyclic compound having many pharmaceutical
and industrial purposes. It can be synthesized by adopting green chemistry principles. The …

Chemistry, Synthesis, and Structure Activity Relationship of Anticancer Quinoxalines

MF Zayed - Chemistry, 2023 - mdpi.com
Quinoxaline is a fused heterocycle system of a benzene ring and pyrazine ring. It has
earned considerable attention due to its importance in the field of medicinal chemistry. The …

Quinoxaline 1, 4-di-N-oxide derivatives: Are they unselective or selective inhibitors?

G Rivera - Mini Reviews in Medicinal Chemistry, 2022 - ingentaconnect.com
Background: For decades, the quinoxaline 1, 4-di-N-oxide ring has been considered a
privileged structure to develop new antibacterial, antitumoural, and antiprotozoal agents …

Advances in antibacterial agents for Mycobacterium fortuitum

CRT Jortieke, AR Joaquim, F Fumagalli - RSC Medicinal Chemistry, 2025 - pubs.rsc.org
Mycobacterium fortuitum is an emerging human pathogen, characterized by an increase in
prevalence and antibacterial resistance over the years, highlighting the need for the …

Organic synthesis and anti-influenza A virus activity of cyclobakuchiols A, B, C, and D

M Shoji, T Esumi, N Tanaka, M Takeuchi, S Yamaji… - Plos one, 2021 - journals.plos.org
Novel antiviral agents for influenza, which poses a substantial threat to humans, are
required. Cyclobakuchiols A and B have been isolated from Psoralea glandulosa, and …