Amyotrophic lateral sclerosis is a late-onset progressive neurodegenerative disease
affecting motor neurons. The etiology of most ALS cases remains unknown, but 2% of …

Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

Glutamate is the principal excitatory neurotransmitter in the nervous system. Inactivation of
synaptic glutamate is handled by the glutamate transporter GLT1 (also known as EAAT2; …

The nucleolus is a key organelle that coordinates the synthesis and assembly of ribosomal
subunits and forms in the nucleus around the repeated ribosomal gene clusters. Because …

ALS is a devastating neurodegenerative disorder with no effective treatment. In the present
study, we found that daily doses of lithium, leading to plasma levels ranging from 0.4 to 0.8 …

The process of neuronal degeneration in motor neurone disease is complex. Several
genetic alterations may be involved in motor neurone injury in familial amyotrophic lateral …

Understanding the means by which microglia self-regulate the neuroinflammatory response
helps modulating their reaction during neurodegeneration. In amyotrophic lateral sclerosis …

Mitochondria are essential for ensuring numerous fundamental physiological processes
such as cellular energy, redox balance, modulation of Ca2+ signaling and important …

Amyotrophic lateral sclerosis (ALS) is an adult‐onset neurodegenerative disease
characterized by the selective death of upper and lower motor neurons which ultimately …

Cortical hyperexcitability has been observed in Amyotrophic Lateral Sclerosis (ALS)
patients. Familial ALS accounts for 10% of all cases and mutations of the Cu, Zn superoxide …