Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Obesity is a triggering factor for diabetes associated with insulin resistance. In individuals
who are obese, higher amounts of non-esterified fatty acids, glycerol, hormones, and pro …

There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …

Studying the metabolism of immune cells in recent years has emphasized the tight link
existing between the metabolic state and the phenotype of these cells. Macrophages in …

Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …

It is well established that muscle contractions during exercise lead to elevated levels of
reactive oxygen species (ROS) in skeletal muscle. These highly reactive molecules have …

Summary mRNA translation is thought to be the most energy-consuming process in the cell.
Translation and energy metabolism are dysregulated in a variety of diseases including …

As NAD+ is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as
a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line …

The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-
1α (PGC-1α) regulates metabolic genes in skeletal muscle and contributes to the response …

Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic
with potential antiaging and antidiabetogenic properties. It is widely consumed as a …