Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various
homeostatic and pathological processes. These activities range from regulating embryonic …

Simple Summary Prostate cancer can develop under hormone treatment and chemotherapy
from a castration-sensitive towards a castration-resistant into a drug resistant-tumor. The …

Using AI, we identified baricitinib as having antiviral and anticytokine efficacy. We now show
a 71%(95% CI 0.15 to 0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV …

Inhibition of the androgen receptor (AR) by second-generation anti-androgens is a standard
treatment for metastatic castration resistant prostate cancer (mCRPC), but it inevitably leads …

Metabolic reprogramming has been recognised as a hallmark in solid tumours. Malignant
modification of the tumour's bioenergetics provides energy for tumour growth and …

The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and
expressed during prostate cancer (PrCa) progression, is a therapeutic target in many …

Simple Summary The primary characteristics of cancer cachexia are weakness, weight loss,
atrophy, fat reduction, and systemic inflammation. Cachexia is strongly associated with …

Muscle cachexia is one of the most critical unmet medical needs. Identifying the molecular
background of cancer-induced muscle loss revealed a promising possibility of new …

Background Dexmedetomidine (DEX), a highly selective α2-adrenergic receptor agonist,
has been reported to increase the malignancy of breast cancer cells in vitro and stimulate …

Prostate cancer (PC) is the most frequently diagnosed cancer and the second leading cause
of cancer-related death in men in the Western society. Unfortunately, although the vast …