[HTML][HTML] Contact system revisited: an interface between inflammation, coagulation, and innate immunity
AT Long, E Kenne, R Jung, TA Fuchs… - Journal of Thrombosis and …, 2016 - Elsevier
The contact system is a plasma protease cascade initiated by factor XII (FXII) that activates
the proinflammatory kallikrein‐kinin system and the procoagulant intrinsic coagulation …
the proinflammatory kallikrein‐kinin system and the procoagulant intrinsic coagulation …
An update on factor XI structure and function
Factor XI (FXI) is the zymogen of a plasma protease, factor XIa (FXIa), that contributes to
thrombin generation during blood coagulation by proteolytic activation of several …
thrombin generation during blood coagulation by proteolytic activation of several …
Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids
Peptides that contain β-amino acids display stable secondary structures, such as helices
and sheets, and are often referred to as foldamers. Cyclic β2, 3-amino acids (cβAAs), such …
and sheets, and are often referred to as foldamers. Cyclic β2, 3-amino acids (cβAAs), such …
Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III
J Björkqvist, S de Maat… - The Journal of …, 2015 - Am Soc Clin Investig
Hereditary angioedema type III (HAEIII) is a rare inherited swelling disorder that is
associated with point mutations in the gene encoding the plasma protease factor XII (FXII) …
associated with point mutations in the gene encoding the plasma protease factor XII (FXII) …
Roles of factor XII in innate immunity
T Renné, EX Stavrou - Frontiers in immunology, 2019 - frontiersin.org
Factor XII (FXII) is the zymogen of serine protease, factor XIIa (FXIIa). FXIIa enzymatic
activities have been extensively studied and FXIIa inhibition is emerging as a promising …
activities have been extensively studied and FXIIa inhibition is emerging as a promising …
An ultrapotent and selective cyclic peptide inhibitor of human β-factor XIIa in a cyclotide scaffold
Cyclotides are plant-derived peptides with complex structures shaped by their head-to-tail
cyclic backbone and cystine knot core. These structural features underpin the native …
cyclic backbone and cystine knot core. These structural features underpin the native …
[HTML][HTML] Protonated-chitosan sponge with procoagulation activity for hemostasis in coagulopathy
Z Huang, D Zhang, L Tong, F Gao, S Zhang, X Wang… - Bioactive Materials, 2024 - Elsevier
Hemostatic materials are essential for managing acute bleeding in medical settings.
Chitosan (CS) shows promise in hemostasis but its underlying mechanism remains …
Chitosan (CS) shows promise in hemostasis but its underlying mechanism remains …
Factor XII/XIIa inhibitors: Their discovery, development, and potential indications
Coagulation factor XII (FXII), a S1A serine protease, was discovered more than fifty years
ago. However, its in vivo functions and its three-dimensional structure started to be disclosed …
ago. However, its in vivo functions and its three-dimensional structure started to be disclosed …
Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation
I Ivanov, A Matafonov, M Sun, Q Cheng… - Blood, The Journal …, 2017 - ashpublications.org
When blood is exposed to variety of artificial surfaces and biologic substances, the plasma
proteins factor XII (FXII) and prekallikrein undergo reciprocal proteolytic conversion to the …
proteins factor XII (FXII) and prekallikrein undergo reciprocal proteolytic conversion to the …
Surface loops of trypsin-like serine proteases as determinants of function
P Goettig, H Brandstetter, V Magdolen - Biochimie, 2019 - Elsevier
Trypsin and chymotrypsin-like serine proteases from family S1 (clan PA) constitute the
largest protease group in humans and more generally in vertebrates. The prototypes …
largest protease group in humans and more generally in vertebrates. The prototypes …