A large proportion of biomedical research and the development of therapeutics is focused
on a small fraction of the human genome. In a strategic effort to map the knowledge gaps …

The synaptic vesicle glycoprotein 2 (SV2) family is comprised of three paralogues: SV2A,
SV2B, and SV2C. In vertebrates, SV2s are 12-transmembrane proteins present on every …

A system-wide understanding of cellular function requires knowledge of all functional
interactions between the expressed proteins. The STRING database aims to collect and …

GeneCards, the human gene compendium, enables researchers to effectively navigate and
inter‐relate the wide universe of human genes, diseases, variants, proteins, cells, and …

Postgenomics data are produced in large volumes by life sciences and clinical applications
of novel omics diagnostics and therapeutics for precision medicine. To move from “data-to …

Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high
impact on school and psychosocial development and high comorbidity with conditions like …

Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a congenital visceral
myopathy characterized by severe dilation of the urinary bladder and defective intestinal …

To date, genome-wide association studies have implicated at least 35 loci in osteoarthritis
but, due to linkage disequilibrium, the specific variants underlying these associations and …

Myosin-I molecular motors are proposed to play various cellular roles related to membrane
dynamics and trafficking. In this Cell Science at a Glance article and the accompanying …

The AAA+ ATPase valosin containing protein (VCP) is essential for cell and organ
homeostasis, especially in cells of the nervous system. As part of a large network, VCP …