PURPOSE: The accumulation of numerous or confluent drusen, especially in the macula, is
a significant risk factor for the development of age-related macular degeneration (AMD) …

Age-related macular degeneration (AMD) is a multifactorial disease influenced by a
combination of environmental factors and genetic variants. Genomic studies have been …

Para-inflammation is a tissue adaptive response to noxious stress or malfunction and has
characteristics that are intermediate between basal and inflammatory states (Medzhitov …

purpose. Dendritic cells (DCs) comprise a system of highly efficient antigen-presenting cells
(APCs) that initiate immune responses. The purpose of this study was to examine the normal …

Aim To determine the sub-macular Bruch's membrane (BrM) macrophage count and the
choroidal and BrM macrophage immunophenotype in normal eyes and in eyes with early …

Age‐related macular degeneration (AMD) is attributed to a complex interaction of genetic
and environmental factors. It is characterized by degeneration involving the retinal …

purpose. To examine the normal murine corneal stroma for the presence of bone marrow-
derived leukocytes. methods. Wholemounts of paraformaldehyde-fixed corneal stroma from …

The eye and the brain are immunologically privileged sites, a property previously attributed
to the lack of a lymphatic circulation. However, recent tracking studies confirm that these …

In the eye immune defenses must take place in a plethora of differing microenvironments
ranging from the corneal and conjunctival epithelia facing the external environment to the …

Plasmacytoid dendritic cells (pDCs) are a unique subpopulation of immune cells, distinct
from classical dendritic cells. pDCs are generated in the bone marrow and following …