Background Missing data may seriously compromise inferences from randomised clinical
trials, especially if missing data are not handled appropriately. The potential bias due to …

Generalized estimating equations (GEE) is a general statistical method to fit marginal
models for longitudinal data in biomedical studies. The variance–covariance matrix of the …

Objective We hypothesized that specific mutations in the β‐glucocerebrosidase gene (GBA)
causing neuropathic Gaucher's disease (GD) in homozygotes lead to aggressive cognitive …

A key driver of patients' well-being and clinical trials for Parkinson's disease (PD) is the
course that the disease takes over time (progression and prognosis). To assess how genetic …

Adolescence is a key developmental period for preventing substance use initiation, however
prevention programs solely providing educational information about the dangers of …

Abstract Background/Aims: Neuropsychiatric symptoms in Alzheimer's disease (AD) are
highly prevalent. We sought to determine whether neuropsychiatric symptoms were related …

Background To investigate whether there are bi-directional associations between anxiety
and mood disorders and body mass index (BMI) in a cohort of young adults. Methods We …

Importance Mortality, morbidity, and health-related quality of life (HRQoL) are patient-
relevant end points generally considered in the early benefit assessments of new cancer …

Neuropsychiatric disorders affect hundreds of millions of patients and families worldwide. To
decode the molecular framework of these diseases, many studies use human postmortem …

There are no cures for neurodegenerative diseases and this is partially due to the difficulty of
monitoring pathogenic molecules in patients during life. The Parkinson's disease gene α …