Occlusive arterial disease is a leading cause of morbidity and mortality worldwide. Aside
from balloon angioplasty, bypass graft surgery is the most commonly performed …

Restenosis is a complex disease for which the pathophysiological mechanisms have not yet
been fully elucidated, but are thought to include inflammation, proliferation, and matrix …

Pericellular proteases play an important role in angiogenesis and vasculogenesis. They
comprise (membrane-type) matrix metalloproteinases [(MT-) MMPs], serine proteases …

Bypass surgery is one of the most frequently used strategies to revascularize tissues
downstream occlusive atherosclerotic lesions. For venous bypass surgery the great …

Adult angiogenesis, associated with pathologic conditions, is often accompanied by the
formation of a fibrinous exudate. This temporary matrix consists mainly of fibrin but is …

The plasminogen activator (PA) system, which controls the formation and activity of plasmin,
plays a key role in modulating hemostasis, thrombosis, and several other biological …

ABSTRACT A novel plasmid-based adenovirus vector system that enables manufacturing of
replication-incompetent (ΔE1) adenovirus type 11 (Ad11)-based vectors is described. Ad11 …

Coronary artery bypass grafting has been utilized as a beneficial treatment for myocardial
ischemic disease for over three decades. Failure of coronary artery venous grafts occurs at a …

The glycolipid-anchored receptor for urokinase-type plasminogen activator (uPAR) is
essential for cell-surface associated plasminogen activation and is overexpressed at the …

To identify improved adenovirus vectors for cardiovascular gene therapy, a library of
adenovirus vectors based on adenovirus serotype 5 (Ad5) but carrying fiber molecules of …