Transcriptional regulators of Na, K-ATPase subunits
Z Li, SA Langhans - Frontiers in cell and developmental biology, 2015 - frontiersin.org
The Na, K-ATPase classically serves as an ion pump creating an electrochemical gradient
across the plasma membrane that is essential for transepithelial transport, nutrient uptake …
across the plasma membrane that is essential for transepithelial transport, nutrient uptake …
The electrophysiological development of cardiomyocytes
The generation of human cardiomyocytes (CMs) from human pluripotent stem cells (hPSCs)
has become an important resource for modeling human cardiac disease and for drug …
has become an important resource for modeling human cardiac disease and for drug …
Reduced Sodium Pump α1, α3, and β1-Isoform Protein Levels and Na+,K+-ATPase Activity but Unchanged Na+-Ca2+ Exchanger Protein Levels in Human …
RHG Schwinger, J Wang, K Frank, J Müller-Ehmsen… - Circulation, 1999 - Am Heart Assoc
Background− Cardiac glycosides initiate an increase in force of contraction by inhibiting the
sarcolemmal sodium pump (Na+, K+-ATPase), thereby decreasing Ca2+ extrusion by the …
sarcolemmal sodium pump (Na+, K+-ATPase), thereby decreasing Ca2+ extrusion by the …
The α1 isoform of Na, K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart
I Dostanic, JEJ Schultz, JN Lorenz, JB Lingrel - Journal of Biological …, 2004 - ASBMB
The primary objective of this study was to examine the functional role of the Na, K-ATPase
α1 isoform in the regulation of cardiac contractility. Previous studies using knock-out mice …
α1 isoform in the regulation of cardiac contractility. Previous studies using knock-out mice …
[HTML][HTML] Sodium kinetics of Na, K-ATPase α isoforms in intact transfected HeLa cells
R Zahler, ZT Zhang, M Manor… - The Journal of general …, 1997 - ncbi.nlm.nih.gov
By participating in the regulation of ion and voltage gradients, the Na-K pump (ie, Na, K-
ATPase) influences many aspects of cellular physiology. Of the four α isoforms of the pump …
ATPase) influences many aspects of cellular physiology. Of the four α isoforms of the pump …
Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart.
J Wang, RH Schwinger, K Frank… - The Journal of …, 1996 - Am Soc Clin Investig
Cardiac glycosides exert a positive inotropic effect by inhibiting sodium pump (Na, K-
ATPase) activity, decreasing the driving force for Na+-Ca++ exchange, and increasing …
ATPase) activity, decreasing the driving force for Na+-Ca++ exchange, and increasing …
Pivotal role of α2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease
Reduced smooth muscle (SM)‐specific α2 Na+ pump expression elevates basal blood
pressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and dietary NaCl, whilst …
pressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and dietary NaCl, whilst …
Effects of two putative endogenous digitalis-like factors, marinobufagenin and ouabain, on the Na+, K+-pump in human mesenteric arteries
AY Bagrov, OV Fedorova - Journal of hypertension, 1998 - journals.lww.com
Objectives Recently, in rat aortae, two putative digitalis-like factors, marinobufagenin and
ouabain, were shown to interact with α-1 (sarcolemma) and α-3 (nerve endings) subunits of …
ouabain, were shown to interact with α-1 (sarcolemma) and α-3 (nerve endings) subunits of …
Intracellular Na+ and altered Na+ transport mechanisms in cardiac hypertrophy and failure
F Verdonck, PGA Volders, MA Vos, KR Sipido - Journal of molecular and …, 2003 - Elsevier
Altered intracellular Na+ ([Na+] i) is a potentially important factor in the functional adaptation
of the hypertrophied and failing heart. We review the currently reported changes in [Na+] i …
of the hypertrophied and failing heart. We review the currently reported changes in [Na+] i …
Thyroid hormone regulates postnatal expression of transient K+ channel isoforms in rat ventricle.
Y Shimoni, C Fiset, RB Clark, JE Dixon… - The Journal of …, 1997 - Wiley Online Library
1. The ability of thyroid hormone to regulate the postnatal changes of the Ca2+‐independent
transient outward K+ current (It) was studied in rat ventricular myocytes. 2. In rat ventricle, It …
transient outward K+ current (It) was studied in rat ventricular myocytes. 2. In rat ventricle, It …