The Na, K-ATPase classically serves as an ion pump creating an electrochemical gradient
across the plasma membrane that is essential for transepithelial transport, nutrient uptake …

The generation of human cardiomyocytes (CMs) from human pluripotent stem cells (hPSCs)
has become an important resource for modeling human cardiac disease and for drug …

Background− Cardiac glycosides initiate an increase in force of contraction by inhibiting the
sarcolemmal sodium pump (Na+, K+-ATPase), thereby decreasing Ca2+ extrusion by the …

The primary objective of this study was to examine the functional role of the Na, K-ATPase
α1 isoform in the regulation of cardiac contractility. Previous studies using knock-out mice …

By participating in the regulation of ion and voltage gradients, the Na-K pump (ie, Na, K-
ATPase) influences many aspects of cellular physiology. Of the four α isoforms of the pump …

Cardiac glycosides exert a positive inotropic effect by inhibiting sodium pump (Na, K-
ATPase) activity, decreasing the driving force for Na+-Ca++ exchange, and increasing …

Reduced smooth muscle (SM)‐specific α2 Na+ pump expression elevates basal blood
pressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and dietary NaCl, whilst …

Objectives Recently, in rat aortae, two putative digitalis-like factors, marinobufagenin and
ouabain, were shown to interact with α-1 (sarcolemma) and α-3 (nerve endings) subunits of …

Altered intracellular Na+ ([Na+] i) is a potentially important factor in the functional adaptation
of the hypertrophied and failing heart. We review the currently reported changes in [Na+] i …

1. The ability of thyroid hormone to regulate the postnatal changes of the Ca2+‐independent
transient outward K+ current (It) was studied in rat ventricular myocytes. 2. In rat ventricle, It …