Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos

BT Mossman, M Lippmann, TW Hesterberg… - Journal of Toxicology …, 2011 - Taylor & Francis
Lung carcinomas and pulmonary fibrosis (asbestosis) occur in asbestos workers.
Understanding the pathogenesis of these diseases is complicated because of potential …

Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases

SXL Huang, MC Jaurand, DW Kamp… - Journal of Toxicology …, 2011 - Taylor & Francis
The cellular and molecular mechanisms of how asbestos fibers induce cancers and other
diseases are not well understood. Both serpentine and amphibole asbestos fibers have …

Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos‐and histology‐related changes in lung cancer

P Nymark, M Guled, I Borze, A Faisal… - Genes …, 2011 - Wiley Online Library
Lung cancer has the highest mortality rate of all of the cancers in the world and asbestos‐
related lung cancer is one of the leading occupational cancers. The identification of …

Arsenic, asbestos and radon: emerging players in lung tumorigenesis

R Hubaux, DD Becker-Santos, KSS Enfield, S Lam… - Environmental …, 2012 - Springer
The cause of lung cancer is generally attributed to tobacco smoking. However lung cancer in
never smokers accounts for 10 to 25% of all lung cancer cases. Arsenic, asbestos and radon …

Hypermethylation of CpG islands and shores around specific microRNAs and mirtrons is associated with the phenotype and presence of bladder cancer

E Dudziec, S Miah, HMZ Choudhry, HC Owen… - Clinical cancer …, 2011 - AACR
Purpose: To analyze the role and translational potential for hypermethylation of CpG islands
and shores in the regulation of small RNAs within urothelial cell carcinoma (UCC). To …

DNA copy number variations as markers of mutagenic impact

G Hovhannisyan, T Harutyunyan… - International journal of …, 2019 - mdpi.com
DNA copy number variation (CNV) occurs due to deletion or duplication of DNA segments
resulting in a different number of copies of a specific DNA-stretch on homologous …

Genomic profiles associated with early micrometastasis in lung cancer: relevance of 4q deletion

M Wrage, S Ruosaari, PP Eijk, JT Kaifi, J Hollmen… - Clinical Cancer …, 2009 - AACR
Purpose: Bone marrow is a common homing organ for early disseminated tumor cells (DTC)
and their presence can predict the subsequent occurrence of overt metastasis and survival …

Gene copy number analysis in malignant pleural mesothelioma using oligonucleotide array CGH

PM Lindholm, K Salmenkivi, H Vauhkonen… - … and genome research, 2007 - karger.com
Conventional cytogenetic analyses and comparative genomic hybridization have revealed a
complex and even chaotic nature of chromosomal aberrations in pleural malignant …

Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines

P Nymark, PM Lindholm, MV Korpela, L Lahti… - BMC genomics, 2007 - Springer
Background Asbestos has been shown to cause chromosomal damage and DNA
aberrations. Exposure to asbestos causes many lung diseases eg asbestosis, malignant …

Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas

VD Martinez, TPH Buys, M Adonis, H Benitez… - British journal of …, 2010 - nature.com
Background: Lung squamous cell carcinomas (SqCCs) occur at higher rates following
arsenic exposure. Somatic DNA copy-number alterations (CNAs) are understood to be …