Type 2 diabetes (T2D) has been rising in prevalence over the past few decades in the US
and worldwide. T2D contributes to significant morbidity and premature mortality, primarily …

Cardiovascular disease (CVD) is a major global cause of mortality, which has prompted
numerous studies seeking to reduce the risk of heart failure and sudden cardiac death …

Exercise-induced physical endurance enhancement and skeletal muscle remodeling can
prevent and delay the development of multiple diseases, especially metabolic syndrome …

Skeletal muscle from the late gestation sheep fetus with intrauterine growth restriction
(IUGR) has evidence of reduced oxidative metabolism. Using a sheep model of placental …

Context The combination of two beneficial antidiabetes interventions, regular exercise and
pharmaceuticals, is intuitively appealing. However, metformin, the most commonly …

Men are diagnosed with type 2 diabetes at lower body mass indexes than women; the role
of skeletal muscle in this sex difference is poorly understood. Type 2 diabetes impacts …

Abstract Type 2 diabetes (T2D) has been rising in prevalence in the United States and
worldwide over the past few decades and contributes to significant morbidity and premature …

Sodium-glucose cotransporter 2 inhibitors (SGLT2is) have been reported to improve obesity,
diabetes, and nonalcoholic fatty liver disease (NAFLD) in addition to exercise training …

Regular exercise and antihyperglycemic drugs are front‐line treatments for type‐2 diabetes
and related metabolic disorders. Leading drugs are metformin, sodium‐glucose …

Key points People with type 2 diabetes (T2D) have impaired skeletal muscle oxidative flux
due to limited oxygen delivery. In the current study, this impairment in oxidative flux in …