Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Most metastasizing tumor cells reach distant sites by entering the circulatory system. Within
the bloodstream, they are exposed to severe stress due to loss of adhesion to extracellular …

The cellular environment where tumor cells reside is called the tumor microenvironment
(TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM) …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

During metastasis, cancer cells disseminate to other parts of the body by entering the
bloodstream in a process that is called intravasation. They then extravasate at metastatic …

Metastatic seeding is driven by cell-intrinsic and environmental cues, yet the contribution of
biomechanics is poorly known. We aim to elucidate the impact of blood flow on the arrest …

Entry of tumor cells into the blood stream is a critical step in cancer metastasis. Although
significant progress has been made in visualizing tumor cell motility in vivo, the underlying …

The process of entering the bloodstream, intravasation, is a necessary step in the
development of distant metastases. The focus of this review is on the pathways and …

Angiogenesis is a critical process required for tumor progression. Newly formed blood
vessels provide nutrition and oxygen to the tumor contributing to its growth and …

The characteristics of the primary tumor blood vessels and the tumor microenvironment drive
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …