Context-specific regulation of extracellular vesicle biogenesis and cargo selection

AC Dixson, TR Dawson, D Di Vizio… - … Reviews Molecular Cell …, 2023 - nature.com
To coordinate, adapt and respond to biological signals, cells convey specific messages to
other cells. An important aspect of cell–cell communication involves secretion of molecules …

Extracellular vesicles and nanoparticles: emerging complexities

DK Jeppesen, Q Zhang, JL Franklin, RJ Coffey - Trends in Cell Biology, 2023 - cell.com
The study of extracellular vesicles (EVs) and nanoparticles (NPs) is rapidly expanding
because recent discoveries have revealed a much greater complexity and diversity than was …

The roles of extracellular vesicles in the immune system

EI Buzas - Nature Reviews Immunology, 2023 - nature.com
The twenty-first century has witnessed major developments in the field of extracellular
vesicle (EV) research, including significant steps towards defining standard criteria for the …

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

L Mashouri, H Yousefi, AR Aref, A Ahadi, F Molaei… - Molecular cancer, 2019 - Springer
Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer
processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion …

The biology of extracellular vesicles: The known unknowns

L Margolis, Y Sadovsky - PLoS biology, 2019 - journals.plos.org
For many years, double-layer phospholipid membrane vesicles, released by most cells,
were not considered to be of biological significance. This stance has dramatically changed …

New technologies for analysis of extracellular vesicles

H Shao, H Im, CM Castro, X Breakefield… - Chemical …, 2018 - ACS Publications
Extracellular vesicles (EVs) are diverse, nanoscale membrane vesicles actively released by
cells. Similar-sized vesicles can be further classified (eg, exosomes, microvesicles) based …

Tumor-derived extracellular vesicles: multifunctional entities in the tumor microenvironment

JW Clancy, C D'Souza-Schorey - Annual Review of Pathology …, 2023 - annualreviews.org
Tumor cells release extracellular vesicles (EVs) that can function as mediators of
intercellular communication in the tumor microenvironment. EVs contain a host of bioactive …

Extracellular vesicles in cancer: cell-to-cell mediators of metastasis

A Becker, BK Thakur, JM Weiss, HS Kim, H Peinado… - Cancer cell, 2016 - cell.com
Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular
communication between tumor cells and stromal cells in local and distant …

Extracellular vesicles: unique intercellular delivery vehicles

SLN Maas, XO Breakefield, AM Weaver - Trends in cell biology, 2017 - cell.com
Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers
with complex cargoes including proteins, lipids, and nucleic acids. While the release of EVs …

Characteristics and significance of the pre-metastatic niche

Y Liu, X Cao - Cancer cell, 2016 - cell.com
Primary tumors create a favorable microenvironment, namely, pre-metastatic niche, in
secondary organs and tissue sites for subsequent metastases. The pre-metastatic niche can …