Abstract Traditional Chinese medicines (TCMs) have been used for preventative care for
thousands of years. The active components are the basis for the pharmacodynamics of …

Inhibiting VEGFR-2 has been set up as a therapeutic strategy for treatment of cancer. Thus,
nineteen new quinazoline-4 (3H)-one derivatives were designed and synthesized …

A series of novel VEGFR-2 inhibitors containing oxime as hinge binding fragment were
described. A strategy of pseudo six-membered ring formed through intramolecular hydrogen …

Targeted anti-tumor small molecules are considered to be promising candidates for cancer
treatment. The novel diphenyl urea derivative (DUD) was synthesized by the molecular …

Forest biomass is viewed as a significant source of organic carbon and thus the ideal
replacement of petroleum products. From the resources derived from biomass …

Abstract A series of N, N'-dibenzoylpiperazine derivatives incorporated with 1H-indazol-3-
amine have been designed, synthesized and evaluated as novel Bcr-Abl inhibitors. Several …

Pathological angiogenesis plays a critical role in numerous diseases including malignancy.
VEGFR-2 is the central regulators in angiogenesis and has become a promising target for …

Recently approved multi-target inhibitors of receptor tyrosine kinases (RTKs) have
significantly improved the clinical treatment of cancers. A series of N, N′-diarylureas …

An efficient regioselective iodination of N-phenylureas was developed using iodine/
trichloroisocyanuric acid in acetonitrile at room temperature. This protocol proved to be …

The increased migration and invasion of breast carcinoma cells are key events in the
development of metastasis to the lymph nodes and distant organs. CXCR 4, the receptor for …