Systemic sclerosis (SSc) is a complex disease characterized by early microvascular
abnormalities, immune dysregulation and chronic inflammation, and subsequent fibrosis of …

Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

Endothelial to mesenchymal transition (EndMT) plays a major role during development, and
also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells …

Objective Systemic sclerosis (SSc) features multiorgan fibrosis orchestrated predominantly
by activated myofibroblasts. Endothelial-to-mesenchymal transition (EndoMT) is a …

Background Plasmacytoid dendritic cells have been implicated in the pathogenesis of
systemic sclerosis through mechanisms beyond the previously suggested production of type …

Objective—Long noncoding RNAs (lncRNAs) represent a rapidly growing class of RNA
genes with functions related primarily to transcriptional and post-transcriptional control of …

Abstract Introduction Systemic sclerosis (SSc) is an autoimmune connective tissue disorder
characterized by fibroproliferative vasculopathy, immunological abnormalities and …

Systemic sclerosis (SSc) is a multisystem autoimmune and vascular disease resulting in
fibrosis of various organs with unknown etiology. Accumulating evidence suggests that a …

Abstract Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors
(S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The …

The role played by T1 IFN and its regulatory genes in SSc is becoming increasingly evident
and strikingly similar to the role observed in SLE. This observation, together with the benefit …