Sarcopenia is generally an age-related condition that directly impacts the quality of life. It is
also related to chronic diseases such as metabolic dysfunction associated with diabetes and …

Life expectancy has drastically increased over the last few decades worldwide, with
important social and medical burdens and costs. To stay healthy longer and to avoid chronic …

Age-dependent loss of skeletal muscle mass and function is a feature of sarcopenia, and
increases the risk of many aging-related metabolic diseases. Here, we report phenotypic …

BACKGROUND: Here, we assessed the role of cellular senescence and the senescence
associated secretory phenotype (SASP) in age-related aortic stiffening and endothelial …

Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …

Delaying and even reversing ageing is a major public health challenge with a tremendous
potential to postpone a plethora of diseases including cancer, metabolic syndromes and …

Senolytics are a category of drugs that reduce the impact of cellular senescence, an effect
associated with a range of chronic and age‐related diseases. Since the discovery of the first …

Cholesterol is an essential component of plasma membrane and precursor of biological
active compounds, including hydroxycholesterols (HCs). HCs regulate cellular homeostasis …

Chronic obstructive pulmonary disease (COPD) is recognized as a disease of accelerated
lung aging. Over the past two decades, mounting evidence suggests an accumulation of …

Doxorubicin (Doxo) is a widely used antineoplastic drug with limited clinical application due
to its deleterious dose-related side effects. We investigated whether nicotinamide …