The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development | ACS
Central Science ACS ACS Publications C&EN CAS Find my institution Log In ACS Central …

Systemic messenger RNA (mRNA) delivery to organs outside the liver, spleen, and lungs
remains challenging. To overcome this issue, we hypothesized that altering nanoparticle …

The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired
one of the most efficient vaccine development campaigns in human history. A key aspect of …

mRNA Lipid nanoparticles (LNPs) have recently been propelled onto the center stage of
therapeutic platforms due to the success of the SARS-CoV-2 mRNA LNP vaccines (mRNA …

Abstract mRNA vaccines have emerged as highly effective strategies in the prophylaxis and
treatment of diseases, thanks largely although not totally to their extraordinary performance …

Highlights•mRNA vaccines address many of the weaknesses of conventional vaccine
types.•Innovations in recent years revolutionized the applicability of mRNA vaccines.•mRNA …

In the past few years, there has been increasing focus on the use of messenger RNA
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …

Therapeutic mRNAs and vaccines are being developed for a broad range of human
diseases, including COVID-19. However, their optimization is hindered by mRNA instability …

In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool
for vaccination. In the following decades, an improved understanding of the mRNA …