Novel DNA sequencing techniques, referred to as “next-generation” sequencing (NGS),
provide high speed and throughput that can produce an enormous volume of sequences …

Many viruses, including the clinically relevant RNA viruses HIV (human immunodeficiency
virus) and HCV (hepatitis C virus), exist in large populations and display high genetic …

RNA viruses within infected individuals exist as a population of evolutionary-related variants.
Owing to evolutionary change affecting the constitution of this population, the frequency …

Recent advances in nucleic acid sequencing technologies, referred to as 'next-generation'
sequencing (NGS), have produced a true revolution and opened new perspectives for …

Population (Sanger) sequencing has been the standard method in basic and clinical DNA
sequencing for almost 40 years; however, next-generation (deep) sequencing …

Allogeneic transplantation with CCR5-delta 32 (CCR5-d32) homozygous stem cells in an
HIV infected individual in 2008, led to a sustained virus control and probably eradication of …

Abstract Background. The Maraviroc versus Optimized Therapy in Viremic Antiretroviral
Treatment-Experienced Patients (MOTIVATE) studies compared maraviroc versus placebo …

Malaria infections commonly contain multiple genetically distinct variants. Mathematical and
animal models suggest that interactions among these variants have a profound impact on …

The broad availability of amplified DNA molecules enabled the development of many
powerful applications in molecular biology techniques. Currently, a variety of DNA …

Combination antiretroviral therapy for HIV-1 infection has resulted in profound reductions in
viremia and is associated with marked improvements in morbidity and mortality. Therapy is …