This mixed design synthesis aimed to estimate the infection fatality rate (IFR) of Coronavirus
Disease 2019 (COVID-19) in community-dwelling elderly populations and other age groups …

Summary Infection with SARS‐CoV‐2, the etiology of the ongoing COVID‐19 pandemic, has
resulted in over 450 million cases with more than 6 million deaths worldwide, causing global …

The latest SARS-CoV-2 variant of concern Omicron, with its immune escape from
therapeutic anti-Spike monoclonal antibodies and WA-1 vaccine-elicited sera, demonstrates …

Vaccination, especially with multiple doses, provides substantial population-level protection
against COVID-19, but emerging variants of concern (VOC) and waning immunity represent …

Background Rapid spread of the omicron SARS-CoV-2 variant despite extensive
vaccination suggests immune escape. The neutralising ability of different vaccines alone or …

SARS-CoV-2-specific T cell response has been proven essential for viral clearance, COVID-
19 outcome and long-term memory. Impaired early T cell-driven immunity leads to a severe …

Summary Background The SARS-CoV-2 omicron variant (B. 1.1. 529) is highly
transmissible, but disease severity appears to be reduced compared with previous variants …

Objectives Seroprevalence studies can provide a measure of SARS-CoV-2 cumulative
incidence, but a better understanding of spike and nucleocapsid (anti-N) antibody dynamics …

Clinical trials and real-world evidence on COVID-19 vaccines have shown their
effectiveness against severe disease and death but the durability of protection remains …

Past severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is an
important determinant of protection from reinfection and of postvaccine immune responses …