Emerging roles and functional mechanisms of PIWI-interacting RNAs
X Wang, A Ramat, M Simonelig, MF Liu - Nature Reviews Molecular …, 2023 - nature.com
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …
PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues
Molecular mechanisms of organismal and cell aging remain incompletely understood. We,
therefore, generated a body-wide map of noncoding RNA (ncRNA) expression in aging (16 …
therefore, generated a body-wide map of noncoding RNA (ncRNA) expression in aging (16 …
Post-transcriptional regulation in spermatogenesis: all RNA pathways lead to healthy sperm
Multiple RNA pathways are required to produce functional sperm. Here, we review RNA post-
transcriptional regulation during spermatogenesis with particular emphasis on the role of …
transcriptional regulation during spermatogenesis with particular emphasis on the role of …
Sperm acrosome overgrowth and infertility in mice lacking chromosome 18 pachytene piRNA
piRNAs are small non-coding RNAs required to maintain genome integrity and preserve
RNA homeostasis during male gametogenesis. In murine adult testes, the highest levels of …
RNA homeostasis during male gametogenesis. In murine adult testes, the highest levels of …
The birth of piRNAs: how mammalian piRNAs are produced, originated, and evolved
Abstract PIWI-interacting RNAs (piRNAs), small noncoding RNAs 24–35 nucleotides long,
are essential for animal fertility. They play critical roles in a range of functions, including …
are essential for animal fertility. They play critical roles in a range of functions, including …
piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis
H Wei, J Gao, DH Lin, R Geng, J Liao… - Nature …, 2024 - nature.com
The intermitochondrial cement (IMC) and chromatoid body (CB) are posited as central sites
for piRNA activity in mice, with MIWI initially assembling in the IMC for piRNA processing …
for piRNA activity in mice, with MIWI initially assembling in the IMC for piRNA processing …
PIWI-interacting RNAs (piRNAs): Promising applications as emerging biomarkers for digestive system cancer
A Cai, Y Hu, Z Zhou, Q Qi, Y Wu, P Dong… - Frontiers in Molecular …, 2022 - frontiersin.org
PIWI-interacting RNAs (piRNAs) are a novel type of small non-coding RNAs (sncRNAs),
which are 26–31 nucleotides in length and bind to PIWI proteins. Although piRNAs were …
which are 26–31 nucleotides in length and bind to PIWI proteins. Although piRNAs were …
MIWI N-terminal RG motif promotes efficient pachytene piRNA production and spermatogenesis independent of LINE1 transposon silencing
C Wei, J Jing, X Yan, JM Mann, R Geng, H Xie… - PLoS …, 2023 - journals.plos.org
PIWI proteins and their associated piRNAs act to silence transposons and promote
gametogenesis. Murine PIWI proteins MIWI, MILI, and MIWI2 have multiple arginine and …
gametogenesis. Murine PIWI proteins MIWI, MILI, and MIWI2 have multiple arginine and …
Building RNA-protein germ granules: insights from the multifaceted functions of DEAD-box helicase Vasa/Ddx4 in germline development
The segregation and maintenance of a dedicated germline in multicellular organisms is
essential for species propagation in the sexually reproducing metazoan kingdom. The …
essential for species propagation in the sexually reproducing metazoan kingdom. The …