Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …

Alzheimer's disease (AD) is a progressive, mental illness without cure. Several years of
intense research on postmortem AD brains, cell and mouse models of AD have revealed …

Physical activity (PA) has been central in the life of our species for most of its history, and
thus shaped our physiology during evolution. However, only recently the health …

Mitochondrial dysfunction represents a well-established player in the pathogenesis of both
monogenic and idiopathic Parkinson's disease (PD). Initially originating from the observation …

Impairments in neuronal intracellular calcium (iCa2+) handling may contribute to
Alzheimer's disease (AD) development. Metabolic dysfunction and progressive neuronal …

Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between
both organelles, but their role in normal and diseased human neurons remains unknown. In …

Proximity labeling catalyzed by promiscuous enzymes, such as TurboID, have enabled the
proteomic analysis of subcellular regions difficult or impossible to access by conventional …

Mitochondria and lysosomes are critical for cellular homeostasis, and dysfunction of both
organelles has been implicated in numerous diseases. Recently, interorganelle contacts …

Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …

Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …