Differential Effects of Sequence-Local versus Nonlocal Charge Patterns on Phase Separation and Conformational Dimensions of Polyampholytes as Model …
Conformational properties of intrinsically disordered proteins (IDPs) are governed by a
sequence-ensemble relationship. To differentiate the impact of sequence-local versus …
sequence-ensemble relationship. To differentiate the impact of sequence-local versus …
Effects of charge asymmetry on the liquid–liquid phase separation of polyampholytes and their condensate properties
Liquid–liquid phase separation (LLPS) is the mechanism underlying the formation of bio-
molecular condensates which are important compartments regulating intra-and extra …
molecular condensates which are important compartments regulating intra-and extra …
Beyond monopole electrostatics in regulating conformations of intrinsically disordered proteins
M Phillips, M Muthukumar, K Ghosh - PNAS nexus, 2024 - academic.oup.com
Conformations and dynamics of an intrinsically disordered protein (IDP) depend on its
composition of charged and uncharged amino acids, and their specific placement in the …
composition of charged and uncharged amino acids, and their specific placement in the …
Physics-Based Machine Learning Trains Hamiltonians and Decodes the Sequence–Conformation Relation in the Disordered Proteome
L Houston, M Phillips, A Torres… - Journal of Chemical …, 2024 - ACS Publications
Intrinsically disordered proteins and regions (IDPs) are involved in vital biological
processes. To understand the IDP function, often controlled by conformation, we need to find …
processes. To understand the IDP function, often controlled by conformation, we need to find …
[HTML][HTML] The Mitochondria Chronicles of Melatonin and ATP: Guardians of Phase Separation
Phase separation is a thermodynamic process used by all living organisms since the origin
of life to rapidly assemble and disassemble membraneless condensates in response to …
of life to rapidly assemble and disassemble membraneless condensates in response to …
[PDF][PDF] Mitochondrial Communications
Phase separation is a thermodynamic process used by all living organisms since the origin
of life to rapidly assemble and disassemble membraneless condensates in response to …
of life to rapidly assemble and disassemble membraneless condensates in response to …