Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and …

A Carey, S Fossati - Alzheimer's & Dementia, 2023 - Wiley Online Library
This review summarizes recent evidence on how mid‐life hypertension,
hyperhomocysteinemia (HHcy) and blood pressure variability, as well as late‐life …

The renin angiotensin system as a therapeutic target in traumatic brain injury

S Villapol, ZC Janatpour, KO Affram, AJ Symes - Neurotherapeutics, 2023 - Elsevier
Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

Protective effect of renin-angiotensin system inhibitors on Parkinson's disease: a nationwide cohort study

Y Jo, S Kim, BS Ye, E Lee, YM Yu - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: Renin-angiotensin system (RAS) inhibitors have been suggested as protective
agents in Parkinson's disease (PD). However, epidemiological evidence on the association …

Neuroprotective effect of angiotensin II receptor blockers on the risk of incident Alzheimer's disease: A nationwide population-based cohort study

HW Lee, S Kim, Y Jo, Y Kim, BS Ye… - Frontiers in Aging …, 2023 - frontiersin.org
Background Recent studies on renin-angiotensin system (RAS) inhibitors have reported a
reduced risk of Alzheimer's disease (AD). Nevertheless, the effect of RAS inhibitor type and …

Brain-penetrant calcium channel blockers are associated with a reduced incidence of neuropsychiatric disorders

L Colbourne, PJ Harrison - Molecular Psychiatry, 2022 - nature.com
Calcium channel blockers (CCBs) differ in their ability to penetrate into the brain.
Pharmacoepidemiological studies suggest that CCBs as a class may have beneficial effects …

Safety and biomarker effects of candesartan in non-hypertensive adults with prodromal Alzheimer's disease

I Hajjar, M Okafor, L Wan, Z Yang, JA Nye… - Brain …, 2022 - academic.oup.com
Observational studies suggest that angiotensin receptor blockers in hypertensive adults are
associated with lower post-mortem indicators of Alzheimer's disease pathology …

Angiotensin receptor blockers and cognition: a scoping review

Z Zhou, SG Orchard, MR Nelson, MA Fravel… - Current hypertension …, 2024 - Springer
Abstract Purpose of Review To provide an overview of the association between angiotensin
II receptor blocker (ARB) use and cognitive outcomes. Recent Findings ARBs have …

Inflammation: a mediator between hypertension and neurodegenerative diseases

J Youwakim, H Girouard - American Journal of Hypertension, 2021 - academic.oup.com
Hypertension is the most prevalent and modifiable risk factor for stroke, vascular cognitive
impairment, and Alzheimer's disease. However, the mechanistic link between hypertension …

Therapeutic Implications of Renin–Angiotensin System Modulators in Alzheimer's Dementia

DC Ababei, V Bild, I Macadan, A Vasincu, RN Rusu… - Pharmaceutics, 2023 - mdpi.com
The Renin–Angiotensin System (RAS) has attracted considerable interest beyond its
traditional cardiovascular role due to emerging data indicating its potential involvement in …

Impact of the renin-angiotensin system on the pathogeny and pharmacotherapeutics of neurodegenerative diseases

W Bild, A Vasincu, RN Rusu, DC Ababei, AB Stana… - Biomolecules, 2022 - mdpi.com
Brain neurodegenerative diseases (BND) are debilitating conditions that are especially
characteristic of a certain period of life and considered major threats to human health …