Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and …
This review summarizes recent evidence on how mid‐life hypertension,
hyperhomocysteinemia (HHcy) and blood pressure variability, as well as late‐life …
hyperhomocysteinemia (HHcy) and blood pressure variability, as well as late‐life …
The renin angiotensin system as a therapeutic target in traumatic brain injury
S Villapol, ZC Janatpour, KO Affram, AJ Symes - Neurotherapeutics, 2023 - Elsevier
Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …
Protective effect of renin-angiotensin system inhibitors on Parkinson's disease: a nationwide cohort study
Background: Renin-angiotensin system (RAS) inhibitors have been suggested as protective
agents in Parkinson's disease (PD). However, epidemiological evidence on the association …
agents in Parkinson's disease (PD). However, epidemiological evidence on the association …
Neuroprotective effect of angiotensin II receptor blockers on the risk of incident Alzheimer's disease: A nationwide population-based cohort study
Background Recent studies on renin-angiotensin system (RAS) inhibitors have reported a
reduced risk of Alzheimer's disease (AD). Nevertheless, the effect of RAS inhibitor type and …
reduced risk of Alzheimer's disease (AD). Nevertheless, the effect of RAS inhibitor type and …
Brain-penetrant calcium channel blockers are associated with a reduced incidence of neuropsychiatric disorders
L Colbourne, PJ Harrison - Molecular Psychiatry, 2022 - nature.com
Calcium channel blockers (CCBs) differ in their ability to penetrate into the brain.
Pharmacoepidemiological studies suggest that CCBs as a class may have beneficial effects …
Pharmacoepidemiological studies suggest that CCBs as a class may have beneficial effects …
Safety and biomarker effects of candesartan in non-hypertensive adults with prodromal Alzheimer's disease
Observational studies suggest that angiotensin receptor blockers in hypertensive adults are
associated with lower post-mortem indicators of Alzheimer's disease pathology …
associated with lower post-mortem indicators of Alzheimer's disease pathology …
Angiotensin receptor blockers and cognition: a scoping review
Abstract Purpose of Review To provide an overview of the association between angiotensin
II receptor blocker (ARB) use and cognitive outcomes. Recent Findings ARBs have …
II receptor blocker (ARB) use and cognitive outcomes. Recent Findings ARBs have …
Inflammation: a mediator between hypertension and neurodegenerative diseases
J Youwakim, H Girouard - American Journal of Hypertension, 2021 - academic.oup.com
Hypertension is the most prevalent and modifiable risk factor for stroke, vascular cognitive
impairment, and Alzheimer's disease. However, the mechanistic link between hypertension …
impairment, and Alzheimer's disease. However, the mechanistic link between hypertension …
Therapeutic Implications of Renin–Angiotensin System Modulators in Alzheimer's Dementia
The Renin–Angiotensin System (RAS) has attracted considerable interest beyond its
traditional cardiovascular role due to emerging data indicating its potential involvement in …
traditional cardiovascular role due to emerging data indicating its potential involvement in …
Impact of the renin-angiotensin system on the pathogeny and pharmacotherapeutics of neurodegenerative diseases
Brain neurodegenerative diseases (BND) are debilitating conditions that are especially
characteristic of a certain period of life and considered major threats to human health …
characteristic of a certain period of life and considered major threats to human health …