The Slit family is a family of secreted proteins that play important roles in various physiologic
and pathologic activities via interacting with Robo receptors. Slit/Robo signaling was first …

Simple Summary Metastatic colorectal cancer (mCRC) has high incidence and mortality.
Nevertheless, innovative biomarkers have been developed for predicting the response to …

Background Circular RNAs (circRNAs) are becoming vital biomarkers and therapeutic
targets for malignant tumors due to their high stability and specificity in tissues. However …

The SLITs (SLIT1, SLIT2, and SLIT3) are a family of secreted proteins that mediate positional
interactions between cells and their environment during development by signaling through …

Cellular metabolic reprogramming is the main characteristic of cancer cells and identification
of targets using this metabolic pattern is extremely important to treat cancers, such as …

Cancer progression and metastasis are processes that involve significant cellular changes.
Many of these changes include alterations in the activity of the Rho GTPase family of …

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Its poor
prognosis is predominantly due to the fact that most patients remain asymptomatic until the …

Abstract Suppressor of variegation 3–9 homolog 2 (SUV39H2) is a member of the SUV39H
subfamily of lysine methyltransferases. Its role in colorectal cancer (CRC) proliferation and …

Background Circular RNAs (circRNAs) are a special class of noncoding RNAs that are
involved in gene regulation and compete with mRNA for miRNA binding sites. The roles of …

Recent studies have revealed that the RNA N 6-methyladenosine (m6A) modification plays
a critical role in a variety of biological processes and associated with multiple diseases …