Parvoviruses, infecting vertebrates and invertebrates, are a family of single-stranded DNA
viruses with small, non-enveloped capsids with T= 1 icosahedral symmetry. A quarter of a …

Decades ago, Friedmann and Roblin postulated several barriers to gene therapy, including
tissue targeting, delivery across the blood–brain barrier (BBB), and host immune responses …

The past few years have seen major advances in our understanding of the controls of
evolution, host range and cell tropism of parvoviruses. Notable findings have included the …

Human parvovirus B19 is the only parvovirus known to be a human pathogen. The structure
of recombinant B19-like particles has been determined to≈ 3.5-Å resolution by x-ray …

Human gene therapy has advanced from twentieth-century conception to twenty-first-century
reality. The recombinant Adeno-Associated Virus (rAAV) is a major gene therapy vector …

Porcine parvovirus (PPV) is considered the main cause of reproductive disorders in pigs,
which are summarized under the acronym SMEDI (stillbirth, mummification, embryonic …

Chapparvoviruses (ChPVs) comprise a divergent, recently identified group of parvoviruses
(family Parvoviridae), associated with nephropathy in immunocompromised laboratory mice …

Parvoviruses elaborate rugged nonenveloped icosahedral capsids of∼ 260 Å in diameter
that comprise just 60 copies of a common core structural polypeptide. While serving as …

This review is a partially personal account of the discovery of virus structure and its
implication for virus function. Although I have endeavored to cover all aspects of structural …

Porcine parvovirus (PPV), recently named Ungulate protoparvovirus 1, is considered to be
one of the most important causes of reproductive failure in swine. Fetal death …