The protamines are a diverse family of small arginine-rich proteins that are synthesized in
the late-stage spermatids of many animals and plants and bind to DNA, condensing the …

BACKGROUND The complexity of fertilization failure during assisted reproductive
technologies (ART) is often under-appreciated, as this failure can occur at any number of …

Existing literature suggests evidence that protamine deficiency is related to DNA damage
and male fertility. In this meta‐analysis, we analyzed the relationship between the ratio of …

Background The first clues to the process of gamete activation date back to nearly 60 years
ago. The mutual activation of gametes is a crucial event during fertilization. In the testis and …

STUDY QUESTION Is the cytoskeletal and chromosomal organization of failed fertilized
oocytes from severely obese patients (BMI≥ 35 kg/m2) altered compared with that in …

OBJECTIVE: To evaluate the influence of DNA fragmentation, DNA methylation, and
protamine deficiency as indicators of chromatin status on assisted reproductive technology …

Telomeres, noncoding and repetitive DNA sequences play a significant function in
chromatin integrity. Telomere length is age‐dependent in somatic cells, while it increases in …

BACKGROUND Reducing the percentage of sperm anomalies in insemination samples
remains a goal to be achieved in the intra-cytoplasmic sperm insemination (ICSI) procedure …

OBJECTIVE: To analyze whether a ready-to-use calcium ionophore improves outcomes,
from fertilization to live birth, in patients with severe male factor infertility. DESIGN: Artificial …

OBJECTIVE: To evaluate efficiency of Ionomycin on fertilization and cleavage rates, embryo
development, and pregnancy rate after intracytoplasmic sperm injection (ICSI) in …