Tumor cell migration and invasion play fundamental roles in cancer metastasis. The
mammalian target of rapamycin (mTOR), a highly conserved and ubiquitously expressed …

The ras genes give rise to a family of related GTP-binding proteins that exhibit potent
transforming potential. Mutational activation of Ras proteins promotes oncogenesis by …

Copper serves as a co-factor for a host of metalloenzymes that contribute to malignant
progression. The orally bioavailable copper chelating agent tetrathiomolybdate (TM) has …

Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that exists in two
separate complexes, mTORC1 and mTORC2, that function to control cell size and growth in …

Melanoma is the foremost malignant cutaneous cancer and it is extremely resistant to
chemotherapy and radiotherapy. Curcumin is an active component of turmeric, the yellow …

Understanding the molecular basis and target of traditional medicine is critical for drug
development. Celastrol, derived from Trypterygium wilfordii Hook F.(“Thunder of God Vine”) …

Background Gastric cancer (GC) is a deadly malignancy worldwide. In the past, it has been
shown that cellular signaling pathway alterations play a crucial role in the development of …

Rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), inhibits tumor cell
motility. However, the underlying mechanism is poorly understood. Here, we show that …

Bee venom is a natural compound produced by the honey bee (Apis mellifera), and has
been reported as having the biological and pharmacological activities, including anti …

Astrocytes in the CNS respond to tissue damage by becoming reactive. They migrate,
undergo hypertrophy, and form a glial scar that inhibits axon regeneration. Therefore …